{"id":"rfd4-proteina","slug":"rfd4-proteina","name":"RFD4-Proteína","orgId":"nvidia","family":"rfd4-proteina","releaseDate":null,"availability":"announced","openWeights":true,"license":null,"paramsTotal":null,"paramsSource":null,"contextWindow":null,"knowledgeCutoff":null,"modelCardUrl":"https://huggingface.co/nvidia/RFD4-Proteina","hfRepo":null,"modalities":["biology"],"aliases":["RFD4-Proteína","rfd4-proteina","rfd4 proteina","rfd4-proteína","nvidia/rfd4-proteina","rfd4-proteina-diffusers","nvidia/rfd4-proteina-diffusers"],"aliasNote":null,"origin":"tracked","tracked":{"trackedSince":"2026-10-20","announced":"2026-10-20","blurb":"NVIDIA and the Baker Lab's flow-matching model for biomolecular design. It generates protein sequences and all-atom structures together, conditioned on the molecular context to preserve: a binding target, an enzyme motif, a ligand or chosen structural features. Weights under BSD 3-Clause. Not an LLM.","api":"none","openWeights":"yes","params":{"text":"About 436M (435,622,465 stored parameters, flow model plus autoencoder)","source":"NVIDIA's Hugging Face model card"},"facts":[{"label":"Developers","value":"Baker Lab (Institute for Protein Design, University of Washington) and NVIDIA GenAIR"},{"label":"Type","value":"Joint sequence-structure generation: a flow model paired with the autoencoder that defines its latent space"},{"label":"Inputs / outputs","value":"Annotated CIF structures or YAML condition specs in; designed structures in CIF with residue identities and coordinates out"},{"label":"Release","value":"2026-10-19 checkpoint pair, with a unified autoencoder covering proteins, nucleic acids and small molecules"},{"label":"License","value":"BSD 3-Clause for the model and weights (optional third-party assets have separate terms)"},{"label":"Code","value":"RosettaCommons/RFD4-Proteina on GitHub; PyPI package rfd4-proteina; Diffusers pipeline pending an open pull request"},{"label":"Hugging Face repo created","value":"Oct 6, 2026 (UTC); announced Oct 20, 2026"}],"sources":[{"kind":"repo","title":"RFD4-Proteina on Hugging Face","url":"https://huggingface.co/nvidia/RFD4-Proteina","date":"2026-10-20"},{"kind":"lab","title":"RFD4-Proteina project page","url":"https://rosettacommons.github.io/RFD4-Proteina/","date":"2026-10-20"},{"kind":"repo","title":"RosettaCommons/RFD4-Proteina on GitHub","url":"https://github.com/RosettaCommons/RFD4-Proteina","date":"2026-10-20"},{"kind":"press","title":"HuggingPapers post on X","url":"https://x.com/HuggingPapers/status/2112621318659281207","date":"2026-10-20"}],"firstBenchmark":null},"organization":{"id":"nvidia","name":"NVIDIA","slug":"nvidia","country":null,"url":null,"color":"#76B900","mark":"N"},"price":null,"answer":{"word":"Pending benchmarks.","scope":"Announced Oct 20, 2026; no independent results yet.","lead":"As of Oct 22, 2026, RFD4-Proteína is pending benchmarks on isitsota: announced Oct 20, 2026, with no independent results on the boards we track yet.","confidence":"low"},"status":"PENDING_BENCHMARKS","verdicts":[]}