Pending benchmarksTracking since Oct 20, 2026
Is RFD4-Proteína state of the art?Pending benchmarks.Announced Oct 20, 2026; no independent results yet.
NVIDIA and the Baker Lab's flow-matching model for biomolecular design. It generates protein sequences and all-atom structures together, conditioned on the molecular context to preserve: a binding target, an enzyme motif, a ligand or chosen structural features. Weights under BSD 3-Clause. Not an LLM.
Announced facts
The details so far
- Lab
- NVIDIA
- Announced
- Oct 20, 2026
- API
- Not yet
- Open weights
- Published
- Parameters
- About 436M (435,622,465 stored parameters, flow model plus autoencoder)
- Developers
- Baker Lab (Institute for Protein Design, University of Washington) and NVIDIA GenAIR
- Type
- Joint sequence-structure generation: a flow model paired with the autoencoder that defines its latent space
- Inputs / outputs
- Annotated CIF structures or YAML condition specs in; designed structures in CIF with residue identities and coordinates out
- Release
- 2026-10-19 checkpoint pair, with a unified autoencoder covering proteins, nucleic acids and small molecules
- License
- BSD 3-Clause for the model and weights (optional third-party assets have separate terms)
- Code
- RosettaCommons/RFD4-Proteina on GitHub; PyPI package rfd4-proteina; Diffusers pipeline pending an open pull request
- Hugging Face repo created
- Oct 6, 2026 (UTC); announced Oct 20, 2026
Tags marked unsure are not stated on the lab's own pages.
Next steps
What would let us call it
Verdicts use only independent boards we already track. Two consecutive snapshots are required before any crown.
- Publicly announced with a source
- Usable by the public (API or weights)
- Listed on an independent board we track
- Enough results for a rank in a category
- Holds across two snapshots (crowns only)
Receipts
Sources
REPORFD4-Proteina on Hugging Facehuggingface.co/nvidia/RFD4-Proteina · Oct 20, 2026LABRFD4-Proteina project pagerosettacommons.github.io/RFD4-Proteina/ · Oct 20, 2026REPORosettaCommons/RFD4-Proteina on GitHubgithub.com/RosettaCommons/RFD4-Proteina · Oct 20, 2026PRESSHuggingPapers post on Xx.com/HuggingPapers/status/2112621318659281207 · Oct 20, 2026Tracking continues until an independent board lists it.